Footnotes

• X @Robichaud_MO, @kevinschroth, @crisdelnevo

• Contributors KRJS and CDD conceptualised the manuscript. MOR and KRJS led the writing of the manuscript with contributions and editing from all co-authors.

• Funding This work was funded in part by grants U01CA278695 and U54CA229973 from the National Cancer Institute and the US Food and Drug Administration. The content is solely the responsibility of the authors and does not necessarily represent the official view of NIH or FDA.

• Competing interests No, there are no competing interests.

• Provenance and peer review Not commissioned; externally peer reviewed.